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New Alert: Cantabio Pharmaceuticals Inc. (OTCQB : CTBO)
Last Close: $2.09
Good Morning Member,
Cantabio Pharmaceuticals (OTCQB: CTBO) is our new biotechnology alert that is focused on developing therapeutic candidates for Alzheimer’s, Parkinson’s, and other neurodegenerative diseases through multiple drug candidates.
Of the top 10 causes of death in America — Alzheimer’s is now No. 6 — it is the only one for which there is no way to prevent it, cure it, or even slow its progression. There are approximately 46 million people worldwide suffering from dementia at an estimated annual cost of $818 billion and reaching $2 trillion annually by 2030.
No current Alzheimer’s drugs on the market have shown any efficacy in reducing the plaque buildups associated with the progression of this devastating and fatal disease.
Cantabio Pharmaceuticals(CTBO) is taking aim at the plaques themselves by locating beta-amyloid and reducing levels in the brain.
CTBO is focused on the novel DJ-1 Protein for both Alzheimer’s and Parkinson’s research. The Michael J. Fox Foundation awarded CTBO(formerly Gardedam Therapeutics) two Rapid Response grants to support CTBO’s small molecule therapeutic project targeting the DJ-1 Protein.
The DJ-1 Protein is considered to be one of the primary therapeutic targets for Parkinson’s disease as it is genetically linked to the onset of “familial” Parkinson’s disease — and loss of its functions is associated with triggering “sporadic” Parkinson’s disease.
On June 16th, 2016, CTBO announced its collaboration with the Neuroscience Research Group at the University of Antioquia in Colombia, to further evaluate the company’s DJ-1 protein-targeting small molecule pharmaceutical chaperone drug candidates in development for the treatment of Parkinson’s disease(PD).
The partnership brings together CTBO's novel approach and the University of Antioquia’s research excellence on the role of oxidative stress in PD and other neurodegenerative diseases.
Research from the ongoing collaboration is elucidating the precise cellular signaling mechanism through which Cantabio’s novel pharmacological chaperone drug candidates produce protective effects in neuron-like cell models. DJ-1 is a key component in the cell’s ability to prevent and reduce damage due to oxidative stress and protein misfolding and is heavily implicated in the onset and progression of PD. Initial results from the collaboration are expected to form part of Cantabio’s presentation of cellular and in vivo results at the 4th World Parkinson Congress taking place in Portland, Oregon in September 20th-23rd 2016.
“These are incredibly exciting times for oxidative stress research,” said professor Velez-Pardo, School of Medicine, Medical Research Institute, Neuroscience Research Group, and University of Antioquia. “Both myself and professor Marlene Jimenez-Del-Rio are pleased to collaborate with Cantabio Pharmaceuticals to better understand the underlying mechanisms of PD and help generate new approaches to treating this insidious and untreatable disorder.”
Gergely Toth, Ph.D., MBA, CEO of Cantabio Therapeutics, Inc. said, "We are privileged to be working with professors Velez-Pardo and Jimenez-Del-Rio and their team. They are leading researchers of oxidative stress signaling mechanisms related to neurodegenerative diseases. Our collaborative research enables us to elucidate the cellular mechanism of action of our pharmaceutical chaperones targeting DJ-1 in more detail. Such insight will provide us a stronger opportunity to translate them into clinical candidates that we hope will improve the prognosis of PD patients. In addition, this relationship underscores our ongoing commitment to working with partners that are at the forefront of science and medicine to continue to develop our exciting portfolio of innovative treatments."
Read the news from Yahoo Finance
On April 12, 2016, CTBO announced a new preclinical therapeutic program for Alzheimer’s Disease which it is pursuing through its drug discovery partnership with NovAliX. This program is aimed at the development of small molecule chaperones that stabilize the Abeta peptide, the aggregation of which is considered to be a key element in the onset and progression of Alzheimer’s disease.
This new program, which is the result of collaborative work between CTBO and NovAliX, is based on the discovery of novel small molecules that interact with the Abeta peptide, which were identified using NovAliX’s high throughput chemical microarray based surface plasmon resonance (SPR-WORM) screen, a unique high throughput biophysics based binding assay platform.
Cantabio(CTBO) aims to develop a novel therapy for the treatment of Alzheimer's disease, which impacts an estimated 5.4 million Americans, including 200,000 individuals below the age of 65. Alzheimer’s is the 6th leading cause of death in the United States, with 700,000 seniors expected to die in 2016 with the disease. The annual number of new cases of Alzheimer's is projected to double by 2050, with a public cost of direct care currently at $236 billion. There is currently no disease modifying treatment available for this growing problem.
NovAliX’s CEO Dr Denis Zeyer said, “We are happy to be working with the Cantabio team to develop exciting new technologies and to showcase the very high potential of the SPR-WORM screen to identify valuable chemical starting points for the targeting of protein – protein interactions. Cantabio’s approach to drug discovery has, we believe, high potential to produce novel, first in class therapies in these disease areas, which have a very high unmet need for disease treating drugs."
Read the release from Yahoo Finance
CTBO has multiple drug candidates and is currently in preclinical stages on 3 seperate DJ-1 Protein studies. Read more about their pipeline here.
CTBO also has a strong team of medical professionals that came together at the prestigious University of Cambridge, England.
In late December, CTBO's CEO, Dr. Gergely Tóth, stated "With recent research establishing a genetic link between the DJ-1 Protein and familial and sporadic Parkinson’s disease, Alzheimer’s disease, and other neurodegenerative diseases, we are particularly
focused on rapidly advancing into clinical trials our novel DJ-1 Protein therapeutic candidates."
CTBO has a dual focus on Alzheimer's and Parkinson's Disease with multiple drugs in the development pipeline on top of an expert scientific team. Make sure to start your research on Cantabio(CTBO).
Small Cap Leader
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